INTRODUCTIONDepression is a state of mind producing a serious,long term lowering of enjoyment of life or inability to visualize a happyfuture. This disease cuts across all races, countries and continents andtherefore should be taken seriously. Depression has been the cause of mostpeople ending their life pre maturely. Hypericum perforatum(St John’s wort:SJW) is a herbal medicine that exerts a range of antidepressant effects,including serotonin, noradrenaline, and dopamine reuptake inhibition, gamma-aminobutyricacid (GABA) and L glutamate pathway modulation, and has an interaction with theneuroendocrine system.WHYI CHOSE ARTICLE #1The main reason I chose to work with article #1 overarticle #2 was simply because article 1 deals with both moderate to milddepression while in Article #2 Citation: Sarris J, Fava M, Schweitzer I, et al.St. John’s wort (Hypericum perforatum) versus sertraline and placebo in majordepressive disorder: continuation data from a 26-week RCT.

Pharmacopsychiatry.2012;45:275–278. PubMedhttp://www.pharmazie.unijena.de/phamedia/LS+Pharmazeutische+Biologie/Seminar_BioIII/15_Johanniskraut.pdf it deals with only major depressive disorder hence it has a certain group inmind already and is not opened to everyone.

CHARACTERISTICSWHY I CHOSE THIS ARTICLEThe first characteristic why I chose article #1 overarticle #2 was because of the objective which I compared before settling onarticle #1.  The objectives of the 2articles vary immensely in article #1 the main objective is to compare theefficacy and tolerability of Hypericum perforatum (St John’s wort extract) withimipramine in patients with mild to moderate depression while in article #2 theobjective was to analyze the extension data from a 26-week randomized, double-blind,restrained study of SJW (LI-160) vs. sertraline and placebo in main depressivedisorder. 124 participant “responders” prolonged treatment from week 8, untilweek 26.

Another characteristic of why I chose this articlewas because of how they were able to select their participants. The method theychose to select participants was,  Womenand Men were included if they were aged 18 or older and found to have  mild to moderate depression without increasedsuicidal ideation or homicidal ideation and if they fulfilled ICD-10(international classification of diseases, 10th revision) criteria for adepressive episode or recurrent depressive disorder (ICD-10 codes F32.0 orF33.

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0 and F32.1 or F33.1). All participants gave written, informed consentbefore entering the study. Partakers were expected to have a score of ?18 on the 17 itemHamilton depression rating scale on consecutive visits to be included in thestudy, the consecutive visits were supposed to be 2. A lot of measures wereused to eliminate people who were not suitable people who were allergic to thedrug, pregnant, breastfeeding or had a serious disease which would havecomplicated the study of the drug hence the findings which they were after wasto be pure facts.The other character why I chose this particulararticle was on how the statistics were analyzed. Specific mental focus was paidto the design and methodology of the research, such as using a sufficientlylarge sample size to allow robust statistical analyses.

The intention to treatanalysis and the analysis of data from participants who complied with theprotocol was planned prospectively. The study wasperformed in compliance with the principles of the Declaration of Helsinki onhuman rights in clinical research and European Union guidelines on goodclinical practice. All efficacy analyses were done on an intention to treatbasis and on the basis of compliance with protocols—that is, only data fromthose participants who were treated for a minimum of 35 days that was analyzed.Safety was evaluated using the intention to treat analysis.Among the factors that can be considered  risky and can lead one to depression includesolitude, history of depression either to the said individual or in the familygene, complicated grief, sleep disturbance and poor health status. Healthpractitioners use  Anxiety and Depressionscales, the patient health questionnaire, the Edinburg postnatal depressionscale for pregnant women and postpartum to find out if someone is sinking intodepression. The age set for screening is above 18. The earlier it is discoveredthe better as it can help someone from sinking deep and loosing hope.

Depression has led to a lot of suicide and substance abuse as recently as lastyear the lead singer of Linkin Park, Bennington Chester took his own life aftera long battle with depression.CONCLUSIONDepression is a risky health issue that needs to beaddressed as we are losing a lot of people through suicides which can bepreventable, also such attacks such as panic attacks and anxiety also lead tomore suicide deaths in the world. Awareness to depression and showering peoplewith love and affection can come in handy when dealing with depression. TheUSPSTF recommends screening and adequate follow up of the patients by medicalpractitioner. A great stride has been taken in developing drugs which helppeople during these hard times.   REFERNCE1.

      WoelkH. Comparison of St John’s wort and imipramine for treating depression:randomised controlled trial. BMJ.

2000 Sep 2;321(7260):536-9.