In today’s world cancer hasbecome one of the major subject of concern despite of large no of therapeuticdrug available. To fight against the cancer cell, a number of strategies likesurgery, chemotherapy, photo-thermal therapy are developed and improved. Incurrent scenario growth of metastatic cancer cell and multidrug resistance(MDR) became the major challenge to the cancer biologist. Various strategiesare made to encounter the multidrug resistance of cancer cell.
A member of ABCfamily which includes P-glycoprotein are commonly present in drug resistancecell and are well known to efflux drug out of the cancer cell making them drugresistance. The other alternative approach for multidrug resistance is tosynthesis anti apoptotic protein. Survivin is one of such anti apoptoticprotein which inhibit the caspases 3 and caspases 9 of the apoptosis pathway. Survivinalso used as a biomarker in many types of drug resistance cancer cell. Variouscompounds with antisense oligonucleotide, transcriptional repressor andimmunotherapy are developed as Survivin inhibition and is now in phase I/II of clinicaltrials.
YM155, GDP366, FL188 are some of the transcriptional repressor drug forSurvivin inhibition that are obtained through high throughput sequencing. For abetter drug delivery, there is still a need for a improvement in developing reliableand efficient delivery of the drug such that it reach to the target site withhigh therapeutic index. With the dawn ofnanotechnology the cancer therapeutics and diagnostic value has improveddrastically. Nanomaterial such as polymer, liposomes, carbon nanotubes,dendrimers, metals such as iron oxide and gold has been vividly employed foranticancer drug delivery.
Conjugation of nanomaterial not only increasestherapeutic index but also enhance the anticancer property of the drug.Nanomaterial conjugate to Survivin inhibitors like GDP366, FL188 or YM155 canhelp to bypass the MDR of cancer cell.