Cancer is one of the chronic
diseases that impose huge pressure on the medical world to tackle the condition
efficiently. Cancer is generally expressed out like a lump of newly growing
tissue, crawling like a crab and penetrating deeper in the host, disturbing the
normal functions of the organs. If a cancer cell dies no cancer can result and
it is deleted from the population and retrieved from reproduction. The problem
arises with the cells that have been damaged to the extent that mechanism
controlling their growth is no longer effective. At some point there is a
switch operating from restrained growth to cancer proliferation favoring the
malignant growth. The etiology for cancer includes wide variety of factors. The
most recent authoritative estimates suggest that up to 80% of cases are due to
causes that are environmental, including diet, lifestyle, specific habits such
as smoking, as well as exposure in the working place. The toxic chemicals
present in out diet, like synthetic or natural chemicals, nature’s pesticides
are carcinogens (Ames, 1989) which have the ability to damage the DNA leading
to cancer.

Breast cancer (BC) is the most
occurring problem of its form where it still remains as the second largest
reason for cancer-related mortalities in women population (Jamal, 2011; DeSantis, 2011). It is observed that nearly 90% cancer
related death is not merely due to the primary tumor, but by the occurrence of metastasis
at distant locations (DeSantis,
2011). Reports tell that approximately 30% of women
diagnosed with early breast cancer have the metastasis or recurrence started
already (O’Shaughnessy, 2005). On the molecular basis,
understanding the mechanism of metastasis is very important in treating breast
cancer. Though precise mechanisms underlying the breast cancer metastasis is either
not discovered or understood fully, studies suggest epithelial-mesenchymal transition
(EMT) could contribute as a major mechanism involved in breast cancer
metastasis (Creighton , 2010). BC is formed when cells
in the breast grow out of control enabling them to invade nearby tissues or
even spread through the body. Any of the types of tissues in the breast can
form cancer cells, but usually cancer comes from either ducts or glands in the
breast. It may take months or years for a tumor to get large enough to get
noticed in the breast, so screening is done using mammograms, to identify the
tumor. 25% to 30% of axillary node positive breast cancer patients get back the
disease within 10 years and proved to be fatal in some cases.


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