Cancer is one of the chronicdiseases that impose huge pressure on the medical world to tackle the conditionefficiently.
Cancer is generally expressed out like a lump of newly growingtissue, crawling like a crab and penetrating deeper in the host, disturbing thenormal functions of the organs. If a cancer cell dies no cancer can result andit is deleted from the population and retrieved from reproduction. The problemarises with the cells that have been damaged to the extent that mechanismcontrolling their growth is no longer effective. At some point there is aswitch operating from restrained growth to cancer proliferation favoring themalignant growth.
The etiology for cancer includes wide variety of factors. Themost recent authoritative estimates suggest that up to 80% of cases are due tocauses that are environmental, including diet, lifestyle, specific habits suchas smoking, as well as exposure in the working place. The toxic chemicalspresent in out diet, like synthetic or natural chemicals, nature’s pesticidesare carcinogens (Ames, 1989) which have the ability to damage the DNA leadingto cancer.Breast cancer (BC) is the mostoccurring problem of its form where it still remains as the second largestreason for cancer-related mortalities in women population (Jamal, 2011; DeSantis, 2011). It is observed that nearly 90% cancerrelated death is not merely due to the primary tumor, but by the occurrence of metastasisat distant locations (DeSantis,2011). Reports tell that approximately 30% of womendiagnosed with early breast cancer have the metastasis or recurrence startedalready (O’Shaughnessy, 2005). On the molecular basis,understanding the mechanism of metastasis is very important in treating breastcancer. Though precise mechanisms underlying the breast cancer metastasis is eithernot discovered or understood fully, studies suggest epithelial-mesenchymal transition(EMT) could contribute as a major mechanism involved in breast cancermetastasis (Creighton , 2010).
BC is formed when cellsin the breast grow out of control enabling them to invade nearby tissues oreven spread through the body. Any of the types of tissues in the breast canform cancer cells, but usually cancer comes from either ducts or glands in thebreast. It may take months or years for a tumor to get large enough to getnoticed in the breast, so screening is done using mammograms, to identify thetumor. 25% to 30% of axillary node positive breast cancer patients get back thedisease within 10 years and proved to be fatal in some cases.
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